Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
نویسندگان
چکیده
منابع مشابه
Opiates modulate thermosensation by internalizing cold receptor TRPM8.
Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabilitation. Unsurprisingly, OPRMs have been a central point of many studies. Non...
متن کاملAnalgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain Running Title: TRPM8 receptor-induced analgesia in neuropathic pain
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متن کاملA hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels.
Temperature transduction in mammals is possible because of the presence of a set of temperature-dependent transient receptor potential (TRP) channels in dorsal root ganglia neurons and skin cells. Six thermo-TRP channels, all characterized by their unusually high temperature sensitivity (Q10 > 10), have been cloned: TRPV1-4 are heat activated, whereas TRPM8 and TRPA1 are activated by cold. Beca...
متن کاملAnalgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain
BACKGROUND Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we de...
متن کاملClues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.
The cold and menthol receptor, TRPM8, also designated CMR1, is a member of the transient receptor potential (TRP) family of excitatory ion channels. TRPM8 is a channel activated by cold temperatures, voltage, and menthol. In this study, we characterize the cold- and voltage-induced activation of TRPM8 channel in an attempt to identify the temperature- and voltage-dependent components involved i...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.07.002